β - adrenergic receptor stimulation inhibits proarrhythmic 1 alternans in post - infarction border zone cardiomyocytes : 2 a computational analysis 3 4
نویسندگان
چکیده
4 Jakub Tomek, Blanca Rodriguez, Gil Bub and Jordi Heijman 5 6 1 Life Sciences Interface Doctoral Training Centre, 7 University of Oxford, Oxford, UK 8 2 Department of Physiology, Anatomy and Genetics, British Heart Foundation Centre of 9 Research Excellence, University of Oxford, Oxford, UK 10 3 Department of Computer Science, British Heart Foundation Centre of Research 11 Excellence, University of Oxford, Oxford, UK 12 4 Department of Physiology, McGill University, Montreal, Quebec, Canada 13 5 Department of Cardiology, CARIM School for Cardiovascular Diseases, Maastricht 14 University, Maastricht, The Netherlands 15 16 Running title: β-AR stimulation and alternans in border zone cardiomyocytes 17 18 Length: 9811 words 19 20 Contributions: designed research (JT), performed simulations (JT, JH), analysed data (JT, 21 BR, GB, JH), designed figures and wrote manuscript (JT, JH), critically revised manuscript 22 (BR, GB) 23 24 Correspondence to: 25 Jakub Tomek 26 Department of Anatomy, Physiology, and Genetics 27 Sherrington Building, Parks Road, Oxford OX1 3PT, United Kingdom 28 E-mail: [email protected] 29 30 OR 31 32 Dr. Jordi Heijman 33 Dept. of Cardiology, CARIM School for Cardiovascular Diseases, Maastricht University 34 PO Box 616; 6200 MD Maastricht, The Netherlands; 35 E-mail: [email protected] 36 Articles in PresS. Am J Physiol Heart Circ Physiol (May 26, 2017). doi:10.1152/ajpheart.00094.2017
منابع مشابه
β-Adrenergic receptor stimulation inhibits proarrhythmic alternans in postinfarction border zone cardiomyocytes: a computational analysis
The border zone (BZ) of the viable myocardium adjacent to an infarct undergoes extensive autonomic and electrical remodeling and is prone to repolarization alternans-induced cardiac arrhythmias. BZ remodeling processes may promote or inhibit Ca2+ and/or repolarization alternans and may differentially affect ventricular arrhythmogenesis. Here, we used a detailed computational model of the canine...
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